Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – aflatrem
Copyright: n/a
Notes:
Species: A. flavus, A. minisclerotigenesSystematic name: 4H-3,15a-Epoxy-1-benzoxepino[6′,7′:6,7]indeno[1,2-b]indol-4-one, 9-(1,1-dimethyl-2-propenyl)-2,3,5b,6,7,7a,8,13,13b,13c,14,15-dodecahydro-5b-hydroxy-2,2,13b,13c-tetramethyl-, (3R,5bS,7aS,13bS,13cR,15aS)-Molecular formulae: C32H39NO4Molecular weight: 501.67Chemical abstracts number: 70553-75-2Selected references: Cole, Richard J.; Dorner, Joe W.; Springer, James P.; Cox, Richard H. (Natl. Peanut Res. Lab., Sci. Educ. Adm., Dawson, GA 31742, USA). J. Agric. Food Chem., 29(2), 293-5 (English) 1981.Toxicity: The first tremorgenic mycotoxin to be isolated. An oral dose of 1 mg given to mice causes tremors, especially in response to attempts to move. The symptoms increase in severity after 1-2 h. but recovery usually occurs after 24-48 h.
Images library
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Mitochondria organisation: GFP fluorescence micrographs showing mitochondrial organisation in an A.nidulans strain with GFP mitochondria, grown at 25°C in minimal media.
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Colony morphology of A.nidulans SRF200 after two days at 37°C
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Aspergillus nidulans. Cell nuclei-Ds red. DsRed fluorescence micrographs showing nuclear distribution in an A.nidulans germling with dsRed stained nuclei
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Cell Biology – Aspergillus nidulans. Cell nuclei-GFP. Nuclear distribution: GFP fluorescence mirographs showing fungal cell morphology and nuclear distribution in A.nidulans. GFP stained nuclei,grown at 25°C in minimal media O/N
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High resolution CT scan of chest.CT scan demonstrating remarkable bronchial wall thickening of the right main bronchus and main branches, in context of longstanding ABPA
