Date: 26 November 2013
Secondary metabolites, structure diagram: Trivial name – aflatoxin M1
Copyright: n/a
Notes:
Species: A. flavus, A. parasiticusSystematic name: Cyclopenta[c]furo[3′,2′:4,5]furo[2,3-h][1]benzopyran-1,11-dione, 2,3,6a,9a-tetrahydro-9a-hydroxy-4-methoxy-, (6aR-cis)-Molecular formulae: C17H12O7Molecular weight: 328.28Chemical abstracts number: 6795-23-9Selected references: Nakazato, Mitsuo; Morozumi, Satoshi; Saito, Kazuo; Fujinuma, Kenji; Nishima, Taichiro; Kasai, Nobuhiko (Dep. Food Hyg. and Nutr., Tokyo Metrop. Res. Lab. Public Health, Tokyo 169, Japan). Eisei Kagaku, 37(2), 107-16 (English) 1991.Toxicity: Slightly less toxic than aflatoxin B1 with an oral LD50 for the one day-old duckling 0.46 mg/kg body-weight. Significantly less carcinogenic than aflatoxin B1.
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Drug rashes: Drug interactions between steroids and anti-fungal drugs – (ecchymosis)
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Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.
Courtesy of Dr D Denning, Wythenshawe Hospital, Manchester.(© Fungal Research Trust),
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Micrographs of A. niger conidia & conidial heads provided by Amaliya Stepanova, Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. terreus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. fumigatus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Patients has history of ABPA complicating long standing asthma. His total IgE has fluctuated between 2,200 and 4,600 KU/L, his Aspergillus IgE between 36.3 and 65.4 kAU/L and Aspergillus IgG from 87-154 mg/L. He has been taking long term itraconazole.
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