Date: 26 November 2013
Secondary metabolites, structural diagram: Trivial name – Phenprocoumon metabolite 2
Copyright: n/a
Notes:
Species: A. nigerSystematic name: 2,4-Cyclohexadien-1-one, 6-(1-hydroxy-2-oxo-3-phenylpentylidene)-, (E)-Molecular formulae: C17H16O3Molecular weight: 268Chemical abstracts number: 119465-31-5Selected references: Microbial models of mammalian metabolism: production of novel a-diketone metabolites of warfarin and phenprocoumon by Aspergillus niger. Rizzo, Jinee D.; Davis, P. J. Coll. Pharm., Univ. Texas, Austin, TX, USA. Xenobiotica (1988), 18(12), 1425-37.
Images library
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Title
Legend
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Necrotic lung tissue in culture
Af=Colony of Aspergillus fumigatus
B=bacterial colonies
L=lung tissue
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A photograph of part of the upper lung lobe of an immunosuppressed patient. The lung tissue shows extenive areas of necrosis due to invasive colonisation.
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A photograph of a cavity in the upper lobe of the lung of a patient with ankylosing spondylitis. Such cavitation,which may be confused with prior tuberculosis, can follow fibrosis.
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Plugs stained with Methenamine/silverActively growing mycelia of the fungus are a deep brown/black. Counterstaining shows the dense mucus of the plugs as predominantly orange.
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Sputum from an asthmatic patient showing plugs(casts). The development of plugs coincided with an increased prevalence and severity of episodes of asthma
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microscopic characters Conidiophore stipes(C)1300-2800um long:Vesicles(V)40-70um wide,clavate:Phialides(Ph) uniseriate:Conidia(Con)3.5-4.0um long,smooth walled.
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microscopic characters Conidiophore stipes(C)225-350um arising from hyphae(Hy):Vesicles(Ves)15-25um wide:Phialides(Ph)uniseriate:Conidia(Con)2.4-3.0um spherical to ovoid,roughened.
