Date: 26 November 2013
Secondary metabolites, structural diagram: Trivial name – Phenprocoumon metabolite 2
Copyright: n/a
Notes:
Species: A. nigerSystematic name: 2,4-Cyclohexadien-1-one, 6-(1-hydroxy-2-oxo-3-phenylpentylidene)-, (E)-Molecular formulae: C17H16O3Molecular weight: 268Chemical abstracts number: 119465-31-5Selected references: Microbial models of mammalian metabolism: production of novel a-diketone metabolites of warfarin and phenprocoumon by Aspergillus niger. Rizzo, Jinee D.; Davis, P. J. Coll. Pharm., Univ. Texas, Austin, TX, USA. Xenobiotica (1988), 18(12), 1425-37.
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High resolution CT scan images with reconstruction of 1mm thick slices at approximately 10mm increments. The scan shows moderately severe multi-lobar cylindrical and varicose bronchiectasis predominantly centrally and in the upper lungs. There is no mucus plugging seen.
The features are in keeping with allergic bronchopulmonary aspergillosis
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pt.SB – 6/10/98 – bronchocentric granulomatosis. CT scan showing multiple small nodules of variable size in both lung fields, apparently close to the vascular bundles.
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Bronchial oedema.Remarkably oedematous bronchial mucosa, as seen in ABPA.
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An example of longstanding allergic bronchopulmonary aspergillosis in a patient who has been steroid dependent for over 15 years showing remarkable kyphoscoliosis and honey combing and fibrosis of both lungs.
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Recurrent pulmonary shadows 1. 6 Jan 1988 – chest radiograph showing right hilar enlargement, consistent with ABPA.
Recurrent pulmonary shadows 1. 3 Feb 1989 – chest radiograph showing right upper-lobe consolidation and contraction consistent with obstruction of RUL bronchus, in ABPA.
Clearing of pulmonary shadows 3, pt BJ. 5 April 1989 – resolution of shadows seen in February, with a course of corticosteroids.
Recurrence of pulmonary shadows 4, pt BJ. 2 September 1989 – recurrence of pulmonary shadows with an exacerbation of ABPA.
Central bronchiectasis, pt BJ. CT scan of thorax October 1989 showing central bronchiectasis, characteristic of ABPA (and cystic fibrosis).
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A typical example of a wet mount of a sputum sample from a patient with allergic bronchopulmonary aspergillosis.