Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – viriditoxin
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Notes:
Species: A. brevipes, A. fumigatus, A. viridinutansSystematic name: (8,8′-Bi-1H-naphtho(2,3-c)pyran)-3,3′-diacetic acid, 3,3′,4,4′-tetrahydro- 9,9′,10,10′-tetrahydroxy-7,7′-dimethoxy-1,1′-dioxo-, dimethyl ester (8,8′-BI-1H-NAPHTHO(2,3-c)PYRAN)-3,3′-DIACETIC ACID, 3,3′,4,4′-TETRAHYDRO-9,9′,1 3,3′,4,4′-Tetrahydro-9,9′,10,Molecular formulae: C34H30O14Molecular weight: 662.594Chemical abstracts number: 35483-50-2Selected references: CURRENT STATUS OF RESEARCH IN MYCOTOXIN-INDUCED TERATOGENESIS HOOD RD; SZCZECH GM EXCERPTA MED INT CONGR SER (426):96,1977TOXINS STACK ME SHERMA, J. AND B. FRIED (ED.). CHROMATOGRAPHIC SCIENCE SERIES, VOL. 71. HANDBOOK OF THIN-LAYER CHROMATOGRAPHY, SECOND EDITION. XV+1104P. MARCEL DEKKER, INC.: NEW YORK, NEW YORK, USA; BASEL, SWITZERLAND. ISBN 0-8247-9454-0.; 71 (0). 1996. 1033-1045.DAVIS ND. Sterigmatocystin and other mycotoxins produced by Aspergillus spp.. J FOOD PROT; 44 (9). 1981. 711-714, 722. Lillehoj EB, Milburn MS. Appl Microbiol. 1973 Aug;26(2):202-5. Viriditoxin production by Aspergillus viridi-nutans and related species.Toxicity: Intraperitoneal LD50 2.8 mg/kg body-weight in male mice.mouse LD50 intraperitoneal 2800ug/kg (2.8mg/kg) CRC Handbook of Antibiotic Compounds, Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 408, 1981.
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Nodules and areas of atelectasis are seen at both bases. He later died.
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It is clearly a relatively small cavitary lesion, and the patient was almost asymptomatic. This response was a ‘stable’ response. The patient was included in the report Denning DW, Lee JY, Hostetler JS, Pappas P, Kauffman CA, Dewsnup DH, Galgiani JN, Graybill JR, Sugar AM, Catanzaro A, Gallis H, Perfect JR, Dockery B, Dismukes WE, Stevens DA, NIAID Mycoses Study Group multicenter trial of oral itraconazole therapy of invasive aspergillosis. Am J Med 1994; 97: 135-144.
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Well demarcated pulmonary infarction is well seen in this close-up of the lung at autopsy in a patient with histologically confirmed invasive aspergillosis. Angio invasion is characteristic of invasive aspergillosis, is associated with a worse prognosis, but is not always seen.
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This 83 year old man presented with weight loss to a lung cancer clinic in mid 2003.
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