Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – viriditoxin
Copyright: n/a
Notes:
Species: A. brevipes, A. fumigatus, A. viridinutansSystematic name: (8,8′-Bi-1H-naphtho(2,3-c)pyran)-3,3′-diacetic acid, 3,3′,4,4′-tetrahydro- 9,9′,10,10′-tetrahydroxy-7,7′-dimethoxy-1,1′-dioxo-, dimethyl ester (8,8′-BI-1H-NAPHTHO(2,3-c)PYRAN)-3,3′-DIACETIC ACID, 3,3′,4,4′-TETRAHYDRO-9,9′,1 3,3′,4,4′-Tetrahydro-9,9′,10,Molecular formulae: C34H30O14Molecular weight: 662.594Chemical abstracts number: 35483-50-2Selected references: CURRENT STATUS OF RESEARCH IN MYCOTOXIN-INDUCED TERATOGENESIS HOOD RD; SZCZECH GM EXCERPTA MED INT CONGR SER (426):96,1977TOXINS STACK ME SHERMA, J. AND B. FRIED (ED.). CHROMATOGRAPHIC SCIENCE SERIES, VOL. 71. HANDBOOK OF THIN-LAYER CHROMATOGRAPHY, SECOND EDITION. XV+1104P. MARCEL DEKKER, INC.: NEW YORK, NEW YORK, USA; BASEL, SWITZERLAND. ISBN 0-8247-9454-0.; 71 (0). 1996. 1033-1045.DAVIS ND. Sterigmatocystin and other mycotoxins produced by Aspergillus spp.. J FOOD PROT; 44 (9). 1981. 711-714, 722. Lillehoj EB, Milburn MS. Appl Microbiol. 1973 Aug;26(2):202-5. Viriditoxin production by Aspergillus viridi-nutans and related species.Toxicity: Intraperitoneal LD50 2.8 mg/kg body-weight in male mice.mouse LD50 intraperitoneal 2800ug/kg (2.8mg/kg) CRC Handbook of Antibiotic Compounds, Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 408, 1981.
Images library
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Title
Legend
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Necrotic lung tissue in culture
Af=Colony of Aspergillus fumigatus
B=bacterial colonies
L=lung tissue
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A photograph of part of the upper lung lobe of an immunosuppressed patient. The lung tissue shows extenive areas of necrosis due to invasive colonisation.
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A photograph of a cavity in the upper lobe of the lung of a patient with ankylosing spondylitis. Such cavitation,which may be confused with prior tuberculosis, can follow fibrosis.
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Plugs stained with Methenamine/silverActively growing mycelia of the fungus are a deep brown/black. Counterstaining shows the dense mucus of the plugs as predominantly orange.
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Sputum from an asthmatic patient showing plugs(casts). The development of plugs coincided with an increased prevalence and severity of episodes of asthma
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microscopic characters Conidiophore stipes(C)1300-2800um long:Vesicles(V)40-70um wide,clavate:Phialides(Ph) uniseriate:Conidia(Con)3.5-4.0um long,smooth walled.
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microscopic characters Conidiophore stipes(C)225-350um arising from hyphae(Hy):Vesicles(Ves)15-25um wide:Phialides(Ph)uniseriate:Conidia(Con)2.4-3.0um spherical to ovoid,roughened.
