Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – viriditoxin
Copyright: n/a
Notes:
Species: A. brevipes, A. fumigatus, A. viridinutansSystematic name: (8,8′-Bi-1H-naphtho(2,3-c)pyran)-3,3′-diacetic acid, 3,3′,4,4′-tetrahydro- 9,9′,10,10′-tetrahydroxy-7,7′-dimethoxy-1,1′-dioxo-, dimethyl ester (8,8′-BI-1H-NAPHTHO(2,3-c)PYRAN)-3,3′-DIACETIC ACID, 3,3′,4,4′-TETRAHYDRO-9,9′,1 3,3′,4,4′-Tetrahydro-9,9′,10,Molecular formulae: C34H30O14Molecular weight: 662.594Chemical abstracts number: 35483-50-2Selected references: CURRENT STATUS OF RESEARCH IN MYCOTOXIN-INDUCED TERATOGENESIS HOOD RD; SZCZECH GM EXCERPTA MED INT CONGR SER (426):96,1977TOXINS STACK ME SHERMA, J. AND B. FRIED (ED.). CHROMATOGRAPHIC SCIENCE SERIES, VOL. 71. HANDBOOK OF THIN-LAYER CHROMATOGRAPHY, SECOND EDITION. XV+1104P. MARCEL DEKKER, INC.: NEW YORK, NEW YORK, USA; BASEL, SWITZERLAND. ISBN 0-8247-9454-0.; 71 (0). 1996. 1033-1045.DAVIS ND. Sterigmatocystin and other mycotoxins produced by Aspergillus spp.. J FOOD PROT; 44 (9). 1981. 711-714, 722. Lillehoj EB, Milburn MS. Appl Microbiol. 1973 Aug;26(2):202-5. Viriditoxin production by Aspergillus viridi-nutans and related species.Toxicity: Intraperitoneal LD50 2.8 mg/kg body-weight in male mice.mouse LD50 intraperitoneal 2800ug/kg (2.8mg/kg) CRC Handbook of Antibiotic Compounds, Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 5, Pg. 408, 1981.
Images library
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Corneal ulcer – gram stain. Corneal scrapings were taken from a 67 yr old farmer presenting with a corneal ulcer of the right eye. A piece of vegetable matter was embedded in the cornea and scrapings were done. Gram stain (500x magnification) showed numerous septate hyphae. Cultures grew a small amount of A fumigatus.
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Corneal ulcer – gram stain. Corneal scrapings were taken from a 67 yr old farmer presenting with a corneal ulcer of the right eye. A piece of vegetable matter was embedded in the cornea and scrapings were done. Gram stain (500x magnification) showed numerous septate hyphae. Cultures grew a small amount of A fumigatus.
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Corneal ulcer – gram stain. Corneal scrapings were taken from a 67 yr old farmer presenting with a corneal ulcer of the right eye. A piece of vegetable matter was embedded in the cornea and scrapings were done. Gram stain (500x magnification) showed numerous septate hyphae. Cultures grew a small amount of A fumigatus.
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Aspergillus keratitis. Central lesion in aspergillus keratitis following a corneal foreign body which made a good response to topical treatment alone, albeit over 2 months intensive treatment.
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Aspergillus keratitis. B- Severe central aspergillus infection with a “cheesey†looking area of the lesion and hypopyon (fluid level of inflammatory cells in the anterior chamber)
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Aspergillus keratitis. A- Severe aspergillus infection with large area of corneal ulceration and deep stromal involvement
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Candida keratitis. Focal candida keratitis as an unusual cause of a suture related infection following corneal transplantation for non infective indication
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Candida keratitis. Subacute onset of candida keratitis in a young adult in whom dust blew into her eye in Greece. A slightly “feathery†edge to stromal involvement is suggestive of fungal infection
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Aspergillus endopthalmitis. Temporal necrosis due to Aspergillus endopthalmitis as part of disseminated disease. No evidence of vitritis. Systemic treatment essential.
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Aspergillus endopthalmitis. Large scarred area of the choroid following healing after Aspergillus endopthalmitis
