Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – viomellein
Copyright: n/a
Notes:
Species: A. melleus, A. ochraceusSystematic name: (8,8′-BI-1H-NAPHTHO(2,3-c)PYRAN)-1,1′,6,9-TETRONE, 3,3′,4,4′-TETRAHYDRO-7,7′-DIM (8,8′-Bi-1H-naphtho(2,3-c)pyran)-1,1′,6,9-tetrone, 3,3′,4,4′-tetrahydro-7,7′-dimethoxy-3,3′-dimethyl-9′,10,10′-trihydroxy-, (R-(R*,R*))-Molecular formulae: C30H24O11Molecular weight: 560.505Chemical abstracts number: 55625-78-0Selected references: Stack ME, Mislivec PB. Production of xanthomegnin and viomellein by isolates of Aspergillus ochraceus, Penicillium cyclopium, and Penicillium viridicatum. Appl Environ Microbiol. 1978 Oct;36(4):552-4. Filtenborg O, Frisvad JC, Svendsen JA. Simple screening method for molds producing intracellular mycotoxins in pure cultures. Appl Environ Microbiol. 1983 Feb;45(2):581-5. Robbers JE, Hong S, Tuite J, Carlton WW. Production of xanthomegnin and viomellein by species of Aspergillus correlated with mycotoxicosis produced in mice. Appl Environ Microbiol. 1978 Dec;36(6):819-23.Toxicity: Causes hepatic and renal damage in animals and associated with porcine nephropathy together with ochratoxins
Images library
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Scanning electron micrograph of Aspergillus ochraceopetaliformis conidial heads
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Image D & E. A case of onychomycosis associated with Aspergillus ochraceopetaliformis as described in Nail infection by Aspergillus ochraceopetaliformis. Med Mycol. 2009 Mar 9:1-5, 2009, Brasch J, Varga J, Jensen JM, Egberts F & Tintelnot K
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Image 5. Oral itraconazole pulse therapy was given to the patient (200 mg twice daily for 1 week, with 3 weeks off between successive pulses, for four pulses) and treatment was successful.
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This patient was 28 yr old with adult lymphocytic leukaemia. She received induction chemotherapy and this infection developed 2 days after recovering from neutropenia.
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Close-up image of the lesion on the left thigh showing a mat of hyphae over the wound.
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Eosinophilic mucin with A. flavus in the nasal cavity. Irregular crust of 2.5 cm from a patient diagnosed as allergic fungal sinusitis. Patient with allergic fungal sinusitis
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GMS stain of eosinophilic mucin reveals a darkly stained dichotomously branched A. flavus hyphae within cellular background. Patient with allergic fungal sinusitis
