Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – Versiconal hemiacetal acetate (1)
Copyright: n/a
Notes:
Species: A. parasiticus, A. versicolorSystematic name: Anthra[2,3-b]furan-5,10-dione, 3-[2-(acetyloxy)ethyl]-2,3-dihydro-2,4,6,8-tetrahydroxy-Molecular formulae: C20H16O9Molecular weight: 400Chemical abstracts number: 62886-00-4Selected references: Steyn, Pieter S.; Vleggaar, Robert; Wessels, Philippus L.; Cole, Richard J.; Scott, De Buys (Natl. Chem. Res. Lab., Counc. Sci. Ind. Res., Pretoria, S. Afr.). J. Chem. Soc., Perkin Trans. 1, (2), 451-9 (English) 1979.
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The chest x-ray shows a patient who had a left lung transplanted in May 2003 for cryptogenic fibrosing alveolitis, which was diagnosed post-transplant as sarcoidosis.
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Gross pathology demonstrating the great pleural thickness and two cavities (upper lobe and superior segment of lower lobe) with fragments of fungal mass.
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Histopathological appearance of a fungus ball. Note a conidial head resulting from fungal exposure to the air.
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Histopathological appearance of a fungus ball caused by Scedosporium apiospermum. The presence of anneloconidia differentiates it from Aspergillus.
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Chronic necrotising aspergillosis. Hyaline hyphal and calcium oxalate crystals obtained by needle aspirate biopsy from a diabetic patient with chronic necrotizing aspergillosis caused by Aspergillus niger (Papanicolaou, x 100).
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Aspergillus niger fungus ball and acute oxalosis. Higher magnification of adjacent replicate section.
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Oxalate crystals within renal tubuli (H&E, phase contrast, x 100). This patient developed acute oxalosis.
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Lung surface. Fungus ball, severe parenchymal fibrosis and pleural thickening.
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