Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – terretonin
Copyright: n/a
Notes:
Species: A. terreusMolecular formulae: C26H3209Selected references: McIntyre, C.R.; Scott, F.E.; Simpson, T.J.; Trimble, L.A. and Vederas, J.C., Application of Stable Isotope Labelling Methodology to the Biosynthesis of the Mycotoxin, Terretonin, by Aspergillus terreus: Incorporation of 13C Labelled Acetates and Methionine, 2H and 13C, 18O Labelled Ethyl 3,5-Dimethylorsellinate and Oxygen-18 Tetrahedron 1989 45 () 2307-2321 J. P. Springer, J. W. Dorner, R. J. Cole, R. H. Cox Terretonin, a Toxic Compound from Aspergillus terreus J. Org. Chem. 1979 44 () 4852-4854
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Drug rashes: Drug interactions between steroids and anti-fungal drugs – (ecchymosis)
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Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.
Courtesy of Dr D Denning, Wythenshawe Hospital, Manchester.(© Fungal Research Trust),
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Micrographs of A. niger conidia & conidial heads provided by Amaliya Stepanova, Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. terreus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. fumigatus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Patients has history of ABPA complicating long standing asthma. His total IgE has fluctuated between 2,200 and 4,600 KU/L, his Aspergillus IgE between 36.3 and 65.4 kAU/L and Aspergillus IgG from 87-154 mg/L. He has been taking long term itraconazole.
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