Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – terretonin
Copyright: n/a
Notes:
Species: A. terreusMolecular formulae: C26H3209Selected references: McIntyre, C.R.; Scott, F.E.; Simpson, T.J.; Trimble, L.A. and Vederas, J.C., Application of Stable Isotope Labelling Methodology to the Biosynthesis of the Mycotoxin, Terretonin, by Aspergillus terreus: Incorporation of 13C Labelled Acetates and Methionine, 2H and 13C, 18O Labelled Ethyl 3,5-Dimethylorsellinate and Oxygen-18 Tetrahedron 1989 45 () 2307-2321 J. P. Springer, J. W. Dorner, R. J. Cole, R. H. Cox Terretonin, a Toxic Compound from Aspergillus terreus J. Org. Chem. 1979 44 () 4852-4854
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Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
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Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.
Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.
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![Asp[1]niger](https://www.aspergillus.org.uk/wp-content/uploads/2013/11/Asp1niger-150x150.gif "Asp[1]niger")
