Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – terrein
Copyright: n/a
Notes:
Species: A. fischeri, A. lentulus, A. monodii, A. monodii, A. novofumigatus, A. olivicola, A. terreus, Emericella variecolor, Emericella venezuelensisSystematic name: 2-Cyclopenten-1-one, 4,5-dihydroxy-3-propenyl- 2-Cyclopenten-1-one, 4,5-dihydroxy-3-(1-propenyl)-Molecular formulae: C8H10O3Molecular weight: 154.163Chemical abstracts number: 582-46-7Selected references: Kiriyama, Noriki; Nitta, Keiichi; Sakaguchi, Yoshiaki; Taguchi, Yasuhisa; Yamamoto, Yuzuru (Fac. Pharm. Sci., Kanazawa Univ., Kanazawa, Japan). Chem. Pharm. Bull., 25(10), 2593-601 (English) 1977.Frisvad JC, Samson RA. Syst Appl Microbiol. 2004 Nov;27(6):672-80. Emericella venezuelensis, a new species with stellate ascospores producing sterigmatocystin and aflatoxin B1.Park SH, Kim DS, Kim WG, Ryoo IJ, Lee DH, Huh CH, Youn SW, Yoo ID, Park KC. Terrein: a new melanogenesis inhibitor and its mechanism. Cell Mol Life Sci. 2004 Nov;61(22):2878-85.
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Nodules and areas of atelectasis are seen at both bases. He later died.
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It is clearly a relatively small cavitary lesion, and the patient was almost asymptomatic. This response was a ‘stable’ response. The patient was included in the report Denning DW, Lee JY, Hostetler JS, Pappas P, Kauffman CA, Dewsnup DH, Galgiani JN, Graybill JR, Sugar AM, Catanzaro A, Gallis H, Perfect JR, Dockery B, Dismukes WE, Stevens DA, NIAID Mycoses Study Group multicenter trial of oral itraconazole therapy of invasive aspergillosis. Am J Med 1994; 97: 135-144.
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Well demarcated pulmonary infarction is well seen in this close-up of the lung at autopsy in a patient with histologically confirmed invasive aspergillosis. Angio invasion is characteristic of invasive aspergillosis, is associated with a worse prognosis, but is not always seen.
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This 83 year old man presented with weight loss to a lung cancer clinic in mid 2003.
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