Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – terrein
Copyright: n/a
Notes:
Species: A. fischeri, A. lentulus, A. monodii, A. monodii, A. novofumigatus, A. olivicola, A. terreus, Emericella variecolor, Emericella venezuelensisSystematic name: 2-Cyclopenten-1-one, 4,5-dihydroxy-3-propenyl- 2-Cyclopenten-1-one, 4,5-dihydroxy-3-(1-propenyl)-Molecular formulae: C8H10O3Molecular weight: 154.163Chemical abstracts number: 582-46-7Selected references: Kiriyama, Noriki; Nitta, Keiichi; Sakaguchi, Yoshiaki; Taguchi, Yasuhisa; Yamamoto, Yuzuru (Fac. Pharm. Sci., Kanazawa Univ., Kanazawa, Japan). Chem. Pharm. Bull., 25(10), 2593-601 (English) 1977.Frisvad JC, Samson RA. Syst Appl Microbiol. 2004 Nov;27(6):672-80. Emericella venezuelensis, a new species with stellate ascospores producing sterigmatocystin and aflatoxin B1.Park SH, Kim DS, Kim WG, Ryoo IJ, Lee DH, Huh CH, Youn SW, Yoo ID, Park KC. Terrein: a new melanogenesis inhibitor and its mechanism. Cell Mol Life Sci. 2004 Nov;61(22):2878-85.
Images library
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Title
Legend
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Necrotic lung tissue in culture
Af=Colony of Aspergillus fumigatus
B=bacterial colonies
L=lung tissue
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A photograph of part of the upper lung lobe of an immunosuppressed patient. The lung tissue shows extenive areas of necrosis due to invasive colonisation.
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A photograph of a cavity in the upper lobe of the lung of a patient with ankylosing spondylitis. Such cavitation,which may be confused with prior tuberculosis, can follow fibrosis.
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Plugs stained with Methenamine/silverActively growing mycelia of the fungus are a deep brown/black. Counterstaining shows the dense mucus of the plugs as predominantly orange.
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Sputum from an asthmatic patient showing plugs(casts). The development of plugs coincided with an increased prevalence and severity of episodes of asthma
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microscopic characters Conidiophore stipes(C)1300-2800um long:Vesicles(V)40-70um wide,clavate:Phialides(Ph) uniseriate:Conidia(Con)3.5-4.0um long,smooth walled.
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microscopic characters Conidiophore stipes(C)225-350um arising from hyphae(Hy):Vesicles(Ves)15-25um wide:Phialides(Ph)uniseriate:Conidia(Con)2.4-3.0um spherical to ovoid,roughened.
