Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – Secalonic acid B
Copyright: n/a
Notes:
Species: A. aculeatusMolecular formulae: C32H30O14 Chemical abstracts number: 35287-71-9Selected references: Kurobane I, Vining LC, McInnes AG. J Antibiot (Tokyo). 1979 Dec;32(12):1256-66. Biosynthetic relationships among the secalonic acids. Isolation of emodin, endocrocin and secalonic acids from Pyrenochaeta terrestris and Aspergillus aculeatus. APSIMON JW, CORRAN JA, CREASEY NG, MARLOW W, WHALLEY WB, SIM KY. THE CHEMISTRY OF FUNGI. XLVII. THE CONSTITUTION OF ERGOCHRYSIN A, SECALONIC ACID A, AND SECALONIC ACID B. J Chem Soc. 1965 Jul;25:4144-56.
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Image A
CT Scan 30/3/99
Showing extreme pleural thickening and 2 small cavities at apex of left lung.
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A 43 year old with smoking related emphysema was admitted to hospital with two separate episodes of haemoptysis. He had been in good health up to 1989, when he was diagnosed as having bilateral pulmonary tuberculosis. At that time a CT scan revealed a cavity in the left upper lobe (20.8cm2) with adjacent confluent infiltrates and pleural thickening. On bronchoscopic examination no abnormalities were noted and endobronchial biopsies did not reveal hyphae.
Over the next 4 years his condition deteriorated and a CT scan showed the left upper lobe cavity had increased to 40cm2. Itraconazole 400mg daily was prescribed. There was some clinical improvement on itraconazole but patient eventually deteriorated with breathlessness and with significant weight loss.
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