Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – Secalonic acid B
Copyright: n/a
Notes:
Species: A. aculeatusMolecular formulae: C32H30O14 Chemical abstracts number: 35287-71-9Selected references: Kurobane I, Vining LC, McInnes AG. J Antibiot (Tokyo). 1979 Dec;32(12):1256-66. Biosynthetic relationships among the secalonic acids. Isolation of emodin, endocrocin and secalonic acids from Pyrenochaeta terrestris and Aspergillus aculeatus. APSIMON JW, CORRAN JA, CREASEY NG, MARLOW W, WHALLEY WB, SIM KY. THE CHEMISTRY OF FUNGI. XLVII. THE CONSTITUTION OF ERGOCHRYSIN A, SECALONIC ACID A, AND SECALONIC ACID B. J Chem Soc. 1965 Jul;25:4144-56.
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Mr RM is 80 and an ex-coal miner.He developed pneumoconiosis from exposure to coal dust. He also developed rheumatoid arthritis and the combination of this disease and pneumoconiosis is called Caplan’s syndrome.
His chest Xray in early 2015 shows extensive bilateral pulmonary shadowing with solid looking nodules superimposed on abnormal lung fields, contraction of his left lung with an elevated diaphragm and a large left upper lobe aspergilloma, displaying a classic air crescent. His CT scan from mid 2014 demonstrates a large aspergilloma in a cavity on the left, with marked pleural thickening around it, which is partially ‘calcified’ towards its base. Inferiorly on other images,remarkable pleural thickening and fibrotic irregular and spiculated nodules are seen, most partially calcified.
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