Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – physcionanthrone
Copyright: n/a
Notes:
Species: A. chevalieriSystematic name: 1,8-Dihydroxy-3-methoxy-6-methylanthrone 9(10H)-Anthracenone, 1,8-dihydroxy-3-methoxy-6-methyl-Molecular formulae: C16H14O4Molecular weight: 270.28Chemical abstracts number: 3571-31-1Selected references: Bachmann M, Blaser P, Luthy J, Schlatter C. J Environ Pathol Toxicol Oncol. 1992 Mar-Apr;11(2):49-52. Toxicity and mutagenicity of anthraquinones from Aspergillus chevalieri.Toxicity: mouse LD50 intraperitoneal 2000ug/kg (2mg/kg) EFFECT: GASTROINTESTINAL: OTHER CHANGES Journal of Agricultural and Food Chemistry. Vol. 27, Pg. 1342, 1979.
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Drug rashes: Drug interactions between steroids and anti-fungal drugs – (ecchymosis)
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Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.
Courtesy of Dr D Denning, Wythenshawe Hospital, Manchester.(© Fungal Research Trust),
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Micrographs of A. niger conidia & conidial heads provided by Amaliya Stepanova, Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. terreus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. fumigatus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Patients has history of ABPA complicating long standing asthma. His total IgE has fluctuated between 2,200 and 4,600 KU/L, his Aspergillus IgE between 36.3 and 65.4 kAU/L and Aspergillus IgG from 87-154 mg/L. He has been taking long term itraconazole.
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