Secondary metabolites, 3D structure: Trivial name – patulin

Date: 26 November 2013

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Secondary metabolites, 3D structure: Trivial name – patulin

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Species: A. clavatonanicus, A. clavatus, A. longivesica, A. terreusSystematic name: 4-Hydroxy-4H-furo(3,2-c)pyran-2(6H)-oneMolecular formulae: C7H6O4Molecular weight: 154.12Chemical abstracts number: 149-29-1Selected references: Waksman SA , et al. The production of two antibacterial substances, fumigacin and clavacin. Science 96: 202-203, 1942Varga J, Rigo K, Molnar J, Toth B, Szencz S, Teren J, Kozakiewicz Z. Antonie Van Leeuwenhoek. 2003;83(2):191-200. Mycotoxin production and evolutionary relationships among species of Aspergillus section Clavati.Sweeney MJ, Dobson AD. Int J Food Microbiol. 1998 Sep 8;43(3):141-58. Mycotoxin production by Aspergillus, Fusarium and Penicillium species.Toxicity: The oral LD50 in rats and mice is 30-35 mg/kg body-weight causing liver, spleen and kidney damage with oedema and haemorrhaging. It has been suspected as carcinogenic for many years and recent assessments of chronic toxicity have not conclusively removed this possibility.

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