Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – O-Methylasparvenone
Copyright: n/a
Notes:
Species: A. parvulusSystematic name: 1(2H)-Naphthalenone, 7-ethyl-3,4-dihydro-4,8-dihydroxy-6-methoxy-, (R)-Molecular formulae: C13H16O4Molecular weight: 236Chemical abstracts number: 56495-98-8Selected references: Metabolites of Aspergilli. Part IV. New naphthalenones and 6-ethyl-7-methoxyjuglone from Aspergillus parvulus. Chao, Pei-Dawn; Schiff, Paul L., Jr.; Slatkin, David J.; Knapp, Joseph E. Sch. Pharm., Univ. Pittsburgh, Pittsburgh, PA, USA. Journal of Chemical Research, Synopses (1979), (7), 236.
Images library
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Image A
CT Scan 30/3/99
Showing extreme pleural thickening and 2 small cavities at apex of left lung.
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A 43 year old with smoking related emphysema was admitted to hospital with two separate episodes of haemoptysis. He had been in good health up to 1989, when he was diagnosed as having bilateral pulmonary tuberculosis. At that time a CT scan revealed a cavity in the left upper lobe (20.8cm2) with adjacent confluent infiltrates and pleural thickening. On bronchoscopic examination no abnormalities were noted and endobronchial biopsies did not reveal hyphae.
Over the next 4 years his condition deteriorated and a CT scan showed the left upper lobe cavity had increased to 40cm2. Itraconazole 400mg daily was prescribed. There was some clinical improvement on itraconazole but patient eventually deteriorated with breathlessness and with significant weight loss.
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