Secondary metabolites, 3D structure: Trivial name - Norisotryptoquivaline

Date: 26 November 2013

Secondary metabolites, 3D structure: Trivial name – Norisotryptoquivaline

Notes:

Species A. fumigatusSystematic name Spiro[furan-2(5H),9′-[9H]imidazo[1,2-a]indole]-3′,5(2’H)-dione, 1′-(acetyloxy)-1′,3,4,9’a-tetrahydro-4-[2-[(1S)-1-hydroxy-2-methylpropyl]-4-oxo-3(4H)-quinazolinyl]-2′-methyl-, (2S,2’S,4R,9’aS)-Molecular formulae C28H28N4O7Molecular weight 532Chemical abstracts number 61897-84-5Selected references Yamazaki, Mikio; Okuyama, Emi; Maebayashi, Yukio (Res. Inst. Chemobiodyn., Chiba Univ., Chiba, Japan). Chem. Pharm. Bull., 27(7), 1611-17 (English) 1979.

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Aspergillus fumigatus Fresen

Aspergillus fumigatus Fresen
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus

Aspergillus flavus
Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920

Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
Aspergillus cretensis

Conidia
Aspergillus cretensis

Seven-day-old cultures on CYA
Aspergillus cretensis

Conidiophores
Aspergillus clavatus

A colour enhanced image.
Cerebral aspergillosis – CT scans, CLL patient DS.

Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.

Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.

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