Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – Nigragillin
Copyright: n/a
Notes:
Species: A. (species not defined)Systematic name: Piperazine, 1,2,5-trimethyl-4-[(2E,4E)-1-oxo-2,4-hexadienyl]-, (2R,5S)-rel-(+)-Molecular formulae: C13H22N2OMolecular weight: 222Chemical abstracts number: 24779-38-2Selected references: Isolation and identification of nigragillin as an insecticidal metabolite produced by Aspergillus niger. Isogai, Akira; Horii, Tetsuo; Suzuki, Akinori; Murakoshi, Shigeo; Ikeda, Katsutoshi; Sato, Shouhachi; Tamura, Saburo. Dep. Agric. Chem., Univ. Tokyo, Tokyo, Japan. Agricultural and Biological Chemistry (1975), 39(3), 739-40. CODEN: ABCHA6 ISSN: 0002-1369.
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Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
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Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.
Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.
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![Asp[1]niger](https://www.aspergillus.org.uk/wp-content/uploads/2013/11/Asp1niger-150x150.gif "Asp[1]niger")
