Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – Mevinolin (lovastatin)
Copyright: n/a
Notes:
Species: A. terreusSystematic name: [3,7-dimethyl-8-[2-(6-oxotetrahydropyran-2-yl)ethyl]-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoateMolecular formulae: C24H36O4Molecular weight: 388.54Chemical abstracts number: 75330-75-5Selected references: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=mesh&dopt=Full&list_uids=68008148
Images library
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Corneal ulcer – gram stain. Corneal scrapings were taken from a 67 yr old farmer presenting with a corneal ulcer of the right eye. A piece of vegetable matter was embedded in the cornea and scrapings were done. Gram stain (500x magnification) showed numerous septate hyphae. Cultures grew a small amount of A fumigatus.
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Corneal ulcer – gram stain. Corneal scrapings were taken from a 67 yr old farmer presenting with a corneal ulcer of the right eye. A piece of vegetable matter was embedded in the cornea and scrapings were done. Gram stain (500x magnification) showed numerous septate hyphae. Cultures grew a small amount of A fumigatus.
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Corneal ulcer – gram stain. Corneal scrapings were taken from a 67 yr old farmer presenting with a corneal ulcer of the right eye. A piece of vegetable matter was embedded in the cornea and scrapings were done. Gram stain (500x magnification) showed numerous septate hyphae. Cultures grew a small amount of A fumigatus.
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Aspergillus keratitis. Central lesion in aspergillus keratitis following a corneal foreign body which made a good response to topical treatment alone, albeit over 2 months intensive treatment.
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Aspergillus keratitis. B- Severe central aspergillus infection with a “cheesey†looking area of the lesion and hypopyon (fluid level of inflammatory cells in the anterior chamber)
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Aspergillus keratitis. A- Severe aspergillus infection with large area of corneal ulceration and deep stromal involvement
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Candida keratitis. Focal candida keratitis as an unusual cause of a suture related infection following corneal transplantation for non infective indication
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Candida keratitis. Subacute onset of candida keratitis in a young adult in whom dust blew into her eye in Greece. A slightly “feathery†edge to stromal involvement is suggestive of fungal infection
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Aspergillus endopthalmitis. Temporal necrosis due to Aspergillus endopthalmitis as part of disseminated disease. No evidence of vitritis. Systemic treatment essential.
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Aspergillus endopthalmitis. Large scarred area of the choroid following healing after Aspergillus endopthalmitis