Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – Mevinolin (lovastatin)
Copyright: n/a
Notes:
Species: A. terreusSystematic name: [3,7-dimethyl-8-[2-(6-oxotetrahydropyran-2-yl)ethyl]-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoateMolecular formulae: C24H36O4Molecular weight: 388.54Chemical abstracts number: 75330-75-5Selected references: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=mesh&dopt=Full&list_uids=68008148
Images library
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Vascular thrombosis. Medium power view (H&E) of a blood vessel occluded by fungal hyphae and thrombosis. Some fungal hyphae can be seen traversing the vessel wall.
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Four colonies of Aspergillus on an agar plate containing rose bengal (to limit colony spending) and elastin fibres (light pink dots). Underneath and surrounding the colonies, the elastin fibres have gone, indicating enzymatic degradation
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High power view of elastin fibres in an arterial wall being forced apart by Aspergillus hyphae. As Aspergillus is angiotropic and produces an elastase, it was uncertain how it traversed vessel walls. It appears to do so without any dissolution of elastin fibres.
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Medium power view (GMS) of hyphae seen within an arterial wall which is characteristic of angioinvasive Aspergillus.
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High power view (H&E) of a branching mould, consistent with Aspergillus inside a giant cell in a patient with chronic granulomatous disease.
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High power view (GMS) of an Aspergillus hypha within a giant cell in a patient with chronic granulomatous disease infected with Aspergillus.
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Medium power view (GMS) of the contents of a cerebral abscess in which there are hyphae typical of Aspergillus. Aspergillus fumigatus was grown from adjacent tissue.
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Low power view (H&E) showing a pulmonary vein and a small bronchus infiltrated by fungal hyphae with associated necrotising inflammation.
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Bilateral A. fumigatus endophthalmitis in association with pulmonary and cerebral aspergillosis, complicating severe autoimmune disease treated with intense immunosuppression. Right eye.
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