Secondary metabolites, 3D structure: Trivial name – Mevinolin (lovastatin)

Date: 26 November 2013

Secondary metabolites, 3D structure: Trivial name – Mevinolin (lovastatin)

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Notes:

Species: A. terreusSystematic name: [3,7-dimethyl-8-[2-(6-oxotetrahydropyran-2-yl)ethyl]-1,2,3,7,8,8a-hexahydronaphthalen-1-yl] 2-methylbutanoateMolecular formulae: C24H36O4Molecular weight: 388.54Chemical abstracts number: 75330-75-5Selected references: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=mesh&dopt=Full&list_uids=68008148

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Nasal, sinus and orbital aspergillosis in a cat. Nose- severe bone erosion rostrally through the nasal bone.

Nasal, sinus and orbital aspergillosis in a cat. Nose- severe bone erosion rostrally through the nasal bone.
Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis as determined by histology.Hyaline, septate and branching hyphae, and asexual reproductive structure of Aspergillus observed in t

Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis as determined by histology.Hyaline, septate and branching hyphae, and asexual reproductive structure of Aspergillus observed in the tissues of Magellanic penguin with fatal aspergillosis. (PAS stain )
Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis as determined by histology. Hyaline, septate and branching hyphae, and asexual reproductive structure of Aspergillus observed in the

Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis as determined by histology. Hyaline, septate and branching hyphae, and asexual reproductive structure of Aspergillus observed in the tissues of Magellanic penguin with fatal aspergillosis. (Grocott’s stain)
Aspergillosis in penguins. Multiple granulomatous nodules at syrinx with necrotic debris and caseous exudates. These lesions were responsible for partial obstruction of the air passages.

Aspergillosis in penguins. Multiple granulomatous nodules at syrinx with necrotic debris and caseous exudates. These lesions were responsible for partial obstruction of the air passages.
Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis as determined by histology. Larges masses formed by multiple nodules in the air sacs and in the adrenal gland.

Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis as determined by histology. Larges masses formed by multiple nodules in the air sacs and in the adrenal gland.
Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis as determined by histology.Adrenal gland involvement (adjacent to kidney) – characterized by massive enlargement to 8-10 cm, form

Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis as determined by histology.Adrenal gland involvement (adjacent to kidney) – characterized by massive enlargement to 8-10 cm, formed by multiple granulomatous nodules.
Aspergillosis in penguins Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis as determined by histology.Adrenal gland involvement (adjacent to kidney) – characterized by massive enlargement to 8-10 cm, forme

Aspergillosis in penguins Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis as determined by histology.Adrenal gland involvement (adjacent to kidney) – characterized by massive enlargement to 8-10 cm, formed by multiple granulomatous nodules.
Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis as determined by histology.Adrenal gland involvement (adjacent to kidney) – characterized by massive enlargement to 8-10 cm, form

Aspergillosis in penguins. Lesions found in captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis as determined by histology.Adrenal gland involvement (adjacent to kidney) – characterized by massive enlargement to 8-10 cm, formed by multiple granulomatous nodules.
Aspergillosis in penguins. Multiple granulomatous nodules in the surface of the kidney

Aspergillosis in penguins. Multiple granulomatous nodules in the surface of the kidney
Aspergillosis in penguins. Lesions found in fatal cases of captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis. Multiple granulomatous nodules in the parenchyma, characterized by friable necrotic lesions with distorted anatomy of

Aspergillosis in penguins. Lesions found in fatal cases of captive Magellanic penguins (Spheniscus magellanicus) with aspergillosis. Multiple granulomatous nodules in the parenchyma, characterized by friable necrotic lesions with distorted anatomy of the organ.