Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – maltoryzine
Copyright: n/a
Notes:
Species: A. oryzae var. microsporusSystematic name: 3-Penten-1-one, 1-(2,3,6-trihydroxyphenyl)- (9CI)Other Names: 3-Pentenophenone, 2′,3′,6′-trihydroxy- (7CI,8CI); Maltoryzin; MaltoryzineMolecular formulae: C11H12O4Molecular weight: 208.211Chemical abstracts number: 6826-42-2Selected references: IIZUKA H, IIDA M. Maltoryzine, a new toxic metabolite produced by a strain of Aspergillus oryzae var. microsporus isolated from the poisonous malt sprout. Nature. 1962 Nov 17;196:681-2.Toxicity: mouse LD50 intraperitoneal 3mg/kg (3mg/kg) EFFECTS: PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) Food and Cosmetics Toxicology. Vol. 1, Pg. 309, 1963.
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Culture plates on different media. A Colonies on CZ at 24oC, B on CYA at 20oC C on SAB at 37oC, D on CYA at 24oC
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Mucous containing Charcot-Leyden crystals, stained with H & EA 57 year old woman presented with breathlessness. She had a history of mild asthma for which she occasionally took salbutamol inhaler puffs. The patient underwent a pneumonectomy because of the severity of her disease process, and uncertainty about the diagnosis, prior to serology results being obtained.Serology showed an IgE of 2600, with a strongly positive Aspergillus RAST test and weakly positive Aspergillus precipitins. Material re
