Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – Malformin C
Copyright: n/a
Notes:
Species: A. nigerSystematic name: 2-[2-[2-[2-(2-aminopropanoylamino)-3-sulfanylidene-propanoyl]amino-3-methyl-butanoyl]amino-4-methyl-pent-4-enoyl]amino-4-methyl-pentanethioic acidMolecular formulae: C23H39N5O5S2Molecular weight: 529.718Chemical abstracts number: 59926-78-2Selected references: KOBBE B ; CUSHMAN M ; WOGAN GN ; DEMAIN AL. Production and antibacterial activity of malformin C, a toxic metabolite of Aspergillus niger. APPL ENVIRON MICROBIOL; 33 (4). 1977 996-997Toxicity: mouse LD50 intraperitoneal 900ug/kg (0.9mg/kg) CRC Handbook of Antibiotic Compounds, Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 309, 1980.
Images library
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The chest x-ray shows a patient who had a left lung transplanted in May 2003 for cryptogenic fibrosing alveolitis, which was diagnosed post-transplant as sarcoidosis.
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Gross pathology demonstrating the great pleural thickness and two cavities (upper lobe and superior segment of lower lobe) with fragments of fungal mass.
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Histopathological appearance of a fungus ball. Note a conidial head resulting from fungal exposure to the air.
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Histopathological appearance of a fungus ball caused by Scedosporium apiospermum. The presence of anneloconidia differentiates it from Aspergillus.
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Chronic necrotising aspergillosis. Hyaline hyphal and calcium oxalate crystals obtained by needle aspirate biopsy from a diabetic patient with chronic necrotizing aspergillosis caused by Aspergillus niger (Papanicolaou, x 100).
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Aspergillus niger fungus ball and acute oxalosis. Higher magnification of adjacent replicate section.
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Oxalate crystals within renal tubuli (H&E, phase contrast, x 100). This patient developed acute oxalosis.
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Lung surface. Fungus ball, severe parenchymal fibrosis and pleural thickening.
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