Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – Malformin C
Copyright: n/a
Notes:
Species: A. nigerSystematic name: 2-[2-[2-[2-(2-aminopropanoylamino)-3-sulfanylidene-propanoyl]amino-3-methyl-butanoyl]amino-4-methyl-pent-4-enoyl]amino-4-methyl-pentanethioic acidMolecular formulae: C23H39N5O5S2Molecular weight: 529.718Chemical abstracts number: 59926-78-2Selected references: KOBBE B ; CUSHMAN M ; WOGAN GN ; DEMAIN AL. Production and antibacterial activity of malformin C, a toxic metabolite of Aspergillus niger. APPL ENVIRON MICROBIOL; 33 (4). 1977 996-997Toxicity: mouse LD50 intraperitoneal 900ug/kg (0.9mg/kg) CRC Handbook of Antibiotic Compounds, Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 309, 1980.
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4 Total obstruction of the sinuses due to inflamed mucosa. (Patient 04)
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1 Axial computed tomography (CT) scans of the frontal sinus.
A: due to the long lasting pressure of mucus, the bone of the anterior wall of frontal sinus is thinned out and elevated anteriorly, forming a bulge. B: same situation as depicted in fig A: the posterior bony wall of frontal sinus is thinned out and extremely elevated posteriorly towards the frontal lobe of the brain. As depicted on the scan, a thin bony layer covering the dura could be recognized intraoperatively
