Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – Malformin C
Copyright: n/a
Notes:
Species: A. nigerSystematic name: 2-[2-[2-[2-(2-aminopropanoylamino)-3-sulfanylidene-propanoyl]amino-3-methyl-butanoyl]amino-4-methyl-pent-4-enoyl]amino-4-methyl-pentanethioic acidMolecular formulae: C23H39N5O5S2Molecular weight: 529.718Chemical abstracts number: 59926-78-2Selected references: KOBBE B ; CUSHMAN M ; WOGAN GN ; DEMAIN AL. Production and antibacterial activity of malformin C, a toxic metabolite of Aspergillus niger. APPL ENVIRON MICROBIOL; 33 (4). 1977 996-997Toxicity: mouse LD50 intraperitoneal 900ug/kg (0.9mg/kg) CRC Handbook of Antibiotic Compounds, Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 4(1), Pg. 309, 1980.
Images library
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Scanning electron micrograph of Aspergillus ochraceopetaliformis conidial heads
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Image D & E. A case of onychomycosis associated with Aspergillus ochraceopetaliformis as described in Nail infection by Aspergillus ochraceopetaliformis. Med Mycol. 2009 Mar 9:1-5, 2009, Brasch J, Varga J, Jensen JM, Egberts F & Tintelnot K
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Image 5. Oral itraconazole pulse therapy was given to the patient (200 mg twice daily for 1 week, with 3 weeks off between successive pulses, for four pulses) and treatment was successful.
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This patient was 28 yr old with adult lymphocytic leukaemia. She received induction chemotherapy and this infection developed 2 days after recovering from neutropenia.
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Close-up image of the lesion on the left thigh showing a mat of hyphae over the wound.
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Eosinophilic mucin with A. flavus in the nasal cavity. Irregular crust of 2.5 cm from a patient diagnosed as allergic fungal sinusitis. Patient with allergic fungal sinusitis
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GMS stain of eosinophilic mucin reveals a darkly stained dichotomously branched A. flavus hyphae within cellular background. Patient with allergic fungal sinusitis
