Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – fumitremorgin A
Copyright: n/a
Notes:
Species: Aspergillus, A. caespitosus, A. egyptiacus, A. fumigatus, Neosartorya fischeriSystematic name: 5H-12H-3,4-Dioxa-5a,11a,15a-triazacyclooct(lm)indeno(5,6-b)fluorene-11,15(2H,13H)-dione, 1,10,10a,14,14a,15b-hexahydro-10a-hydroxy-7-methoxy-2,2-dimethyl-10-((3-methyl-2-butenyl)oxy)-5-(2-methyl-1-propenyl)-, (5R,10S,10aR,14aS,15bS)-Molecular formulae: C32H41N3O7Molecular weight: 579.684Chemical abstracts number: 12626-18-5Selected references: Yamazaki, Mikio; Fujimoto, Haruhiro; Kawasaki, Takao (Res. Inst. Chemobiodyn., Chiba Univ., Chiba 280, Japan). Chem. Pharm. Bull., 28(1), 245-254 (English) 1980.Toxicity: A tremorgenic mycotoxin. Intraperitoneal injection of 1 mg in mice caused visible tremors and a dose of 5 mg caused both sustained tremors and 70% mortality.
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Culture plates on different media. A Colonies on CZ at 24oC, B on CYA at 20oC C on SAB at 37oC, D on CYA at 24oC
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Mucous containing Charcot-Leyden crystals, stained with H & EA 57 year old woman presented with breathlessness. She had a history of mild asthma for which she occasionally took salbutamol inhaler puffs. The patient underwent a pneumonectomy because of the severity of her disease process, and uncertainty about the diagnosis, prior to serology results being obtained.Serology showed an IgE of 2600, with a strongly positive Aspergillus RAST test and weakly positive Aspergillus precipitins. Material re
