Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – fumitremorgin A
Copyright: n/a
Notes:
Species: Aspergillus, A. caespitosus, A. egyptiacus, A. fumigatus, Neosartorya fischeriSystematic name: 5H-12H-3,4-Dioxa-5a,11a,15a-triazacyclooct(lm)indeno(5,6-b)fluorene-11,15(2H,13H)-dione, 1,10,10a,14,14a,15b-hexahydro-10a-hydroxy-7-methoxy-2,2-dimethyl-10-((3-methyl-2-butenyl)oxy)-5-(2-methyl-1-propenyl)-, (5R,10S,10aR,14aS,15bS)-Molecular formulae: C32H41N3O7Molecular weight: 579.684Chemical abstracts number: 12626-18-5Selected references: Yamazaki, Mikio; Fujimoto, Haruhiro; Kawasaki, Takao (Res. Inst. Chemobiodyn., Chiba Univ., Chiba 280, Japan). Chem. Pharm. Bull., 28(1), 245-254 (English) 1980.Toxicity: A tremorgenic mycotoxin. Intraperitoneal injection of 1 mg in mice caused visible tremors and a dose of 5 mg caused both sustained tremors and 70% mortality.
Images library
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4 Total obstruction of the sinuses due to inflamed mucosa. (Patient 04)
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1 Axial computed tomography (CT) scans of the frontal sinus.
A: due to the long lasting pressure of mucus, the bone of the anterior wall of frontal sinus is thinned out and elevated anteriorly, forming a bulge. B: same situation as depicted in fig A: the posterior bony wall of frontal sinus is thinned out and extremely elevated posteriorly towards the frontal lobe of the brain. As depicted on the scan, a thin bony layer covering the dura could be recognized intraoperatively
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2 Same patient as 1 and 3, frontal CT
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D. 6 months later, tenacious yellow secretions in L basal bronchial division
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C. After suction the material was seen to extend distally – obstructing the right basal stem bronchus
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B. After suction the material was seen to extend distally – obstructing the right basal stem bronchus
