Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – fumitremorgin A
Copyright: n/a
Notes:
Species: Aspergillus, A. caespitosus, A. egyptiacus, A. fumigatus, Neosartorya fischeriSystematic name: 5H-12H-3,4-Dioxa-5a,11a,15a-triazacyclooct(lm)indeno(5,6-b)fluorene-11,15(2H,13H)-dione, 1,10,10a,14,14a,15b-hexahydro-10a-hydroxy-7-methoxy-2,2-dimethyl-10-((3-methyl-2-butenyl)oxy)-5-(2-methyl-1-propenyl)-, (5R,10S,10aR,14aS,15bS)-Molecular formulae: C32H41N3O7Molecular weight: 579.684Chemical abstracts number: 12626-18-5Selected references: Yamazaki, Mikio; Fujimoto, Haruhiro; Kawasaki, Takao (Res. Inst. Chemobiodyn., Chiba Univ., Chiba 280, Japan). Chem. Pharm. Bull., 28(1), 245-254 (English) 1980.Toxicity: A tremorgenic mycotoxin. Intraperitoneal injection of 1 mg in mice caused visible tremors and a dose of 5 mg caused both sustained tremors and 70% mortality.
Images library
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Scanning electron micrograph of Aspergillus ochraceopetaliformis conidial heads
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Image D & E. A case of onychomycosis associated with Aspergillus ochraceopetaliformis as described in Nail infection by Aspergillus ochraceopetaliformis. Med Mycol. 2009 Mar 9:1-5, 2009, Brasch J, Varga J, Jensen JM, Egberts F & Tintelnot K
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Image 5. Oral itraconazole pulse therapy was given to the patient (200 mg twice daily for 1 week, with 3 weeks off between successive pulses, for four pulses) and treatment was successful.
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This patient was 28 yr old with adult lymphocytic leukaemia. She received induction chemotherapy and this infection developed 2 days after recovering from neutropenia.
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Close-up image of the lesion on the left thigh showing a mat of hyphae over the wound.
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Eosinophilic mucin with A. flavus in the nasal cavity. Irregular crust of 2.5 cm from a patient diagnosed as allergic fungal sinusitis. Patient with allergic fungal sinusitis
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GMS stain of eosinophilic mucin reveals a darkly stained dichotomously branched A. flavus hyphae within cellular background. Patient with allergic fungal sinusitis
