Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – fumitremorgin A
Copyright: n/a
Notes:
Species: Aspergillus, A. caespitosus, A. egyptiacus, A. fumigatus, Neosartorya fischeriSystematic name: 5H-12H-3,4-Dioxa-5a,11a,15a-triazacyclooct(lm)indeno(5,6-b)fluorene-11,15(2H,13H)-dione, 1,10,10a,14,14a,15b-hexahydro-10a-hydroxy-7-methoxy-2,2-dimethyl-10-((3-methyl-2-butenyl)oxy)-5-(2-methyl-1-propenyl)-, (5R,10S,10aR,14aS,15bS)-Molecular formulae: C32H41N3O7Molecular weight: 579.684Chemical abstracts number: 12626-18-5Selected references: Yamazaki, Mikio; Fujimoto, Haruhiro; Kawasaki, Takao (Res. Inst. Chemobiodyn., Chiba Univ., Chiba 280, Japan). Chem. Pharm. Bull., 28(1), 245-254 (English) 1980.Toxicity: A tremorgenic mycotoxin. Intraperitoneal injection of 1 mg in mice caused visible tremors and a dose of 5 mg caused both sustained tremors and 70% mortality.
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Bronchoscopic manifestations of Aspergillus tracheobronchitis. (a) Type I. Inflammatory infiltration, mucosa hyperaemia and plaques of pseudomembrane formation in the lumen without obvious airway occlusion. (b) Type II. Deep ulceration of the bronchial wall. (c) Type III. Significant airway occlusion by thick mucous plugs full of Aspergillus without definite deeper tissue invasion. (d) Type IV. Extensive tissue necrosis and pseudomembrane formation in the lumen with airway structures and severe airway occlusion (Wu 2010).
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High resolution CT showing centrilobular nodular opacities and branching linear opacities (tree-in-bud appearance) (Al-Alawi 2007).
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Chest X-ray showing poorly defined bilateral nodular opacities (Al-Alawi 2007).
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Gross pathologic specimen from autopsy shows the bronchial lumen covered by multiple whitish endobronchial nodules (arrows) (Franquet 2002).
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Invasive tracheobronchitis showing numerous nodules seen during bronchoscopy (Ronan D’Driscoll).
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Pseudomembranous seen overlying the bronchial mucosa (Tasci 2006).
