Secondary metabolites, 3D structure: Trivial name – fumigaclavine A

Date: 26 November 2013

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Secondary metabolites, 3D structure: Trivial name – fumigaclavine A

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Notes:

Species: A. fumigatus, A. tamariiSystematic name: Ergolin-9-ol, 6,8-dimethyl-, acetate (ester), (8-alpha,9-beta)-Molecular formulae: C18 H22 N2 O2Molecular weight: 298.38Chemical abstracts number: 6879-59-0Selected references: COLE RJ, KIRKSEY JW, DORNER JW, WILSON DM, JOHNSON J C JR’ JOHNSON AN, BEDELL DM, SPRINGER JP, CHEXAL KK, ET AL. J AGRIC FOOD CHEM; 25 (4). 1977 826-830Toxicity: The LD50 of fumigaclavine C was about 150 mg/kg oral dose in day-old cockerels. Calves dosed with crude extracts of A. fumigatus cultures experienced severe diarrhea, irritability and loss of appetite. Postmortem examination showed serous enteritis and evidence of interstitial changes in the lungs; abnormal changes were not found in other tissues.

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