Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – dihydrocitrinone
Copyright: n/a
Notes:
Species: A. carneusSystematic name: 1H-2-Benzopyran-7-carboxylic acid, 3,4-dihydro-6,8-dihydroxy-3,4,5-trimethyl-1-oxo-, (3R,4S)-Molecular formulae: C13H14O6Molecular weight: 266Chemical abstracts number: 65718-85-6Selected references: Chien, M. M.; Schiff, P. L., Jr.; Slatkin, D. J.; Knapp, J. E. (Sch. Pharm., Univ. Pittsburgh, Pittsburgh, Pa., USA). Lloydia, 40(3), 301-2 (English) 1977.
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Aspergillus flavus Link. A colonies after 1 weekB,C conidial heads x 920D Conidia x920 E Conidial head x920
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Patient diagnosed with Stage C Chronic Lymphocytic Leukaemia, treated in the MRC CLL4 study, with prednisolone for 4 weeks followed by oral chlorambucil for 7 days. Patient developed severe pneumonia due to pseudomonas and staphylococcus. Following treatment with broad spectrum antibiotics and 1 week of Abelcet, patient was readmitted with headache, disorientation and fever. CT brain scans showed 3 ring enhancing lesions, aspirated material showed neutrophils but grew aspergillus. Patient now improved on Abelcet (4 mg/kg) and oral itrconazole suspension 200mg b.d.
Thanks to Richard Chasty, Consultant Haematologist, North Staffordsire Hospital, UK.,