Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – chloromethyresorcyloylhydroxyanisinate
Copyright: n/a
Notes:
Species: A. aureusSystematic name: Benzoic acid, 5-(acetyloxy)-2-[2,6-bis(acetyloxy)-3,5-dichloro-4-methylbenzoyl]-3-methoxy-, methyl esterMolecular formulae: C23H20Cl2O10Molecular weight: 526Chemical abstracts number: 89367-82-8Selected references: Inamori, Yoshihiko; Kato, Yoshiaki; Kubo, Mayuri; Kamiki, Teruo; Takemoto, Tsunematsu; Nomoto, Kyosuke. Studies on metabolites produced by Aspergillus terreus var. aureus. I. Chemical structures and antimicrobial activities of metabolites isolated from culture broth. Chemical & Pharmaceutical Bulletin (1983), 31(12), 4543-8.
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Drug rashes: Drug interactions between steroids and anti-fungal drugs – (ecchymosis)
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Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.
Courtesy of Dr D Denning, Wythenshawe Hospital, Manchester.(© Fungal Research Trust),
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Micrographs of A. niger conidia & conidial heads provided by Amaliya Stepanova, Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. terreus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. fumigatus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Patients has history of ABPA complicating long standing asthma. His total IgE has fluctuated between 2,200 and 4,600 KU/L, his Aspergillus IgE between 36.3 and 65.4 kAU/L and Aspergillus IgG from 87-154 mg/L. He has been taking long term itraconazole.
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