Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – chloromethyresorcyloylhydroxyanisinate
Copyright: n/a
Notes:
Species: A. aureusSystematic name: Benzoic acid, 5-(acetyloxy)-2-[2,6-bis(acetyloxy)-3,5-dichloro-4-methylbenzoyl]-3-methoxy-, methyl esterMolecular formulae: C23H20Cl2O10Molecular weight: 526Chemical abstracts number: 89367-82-8Selected references: Inamori, Yoshihiko; Kato, Yoshiaki; Kubo, Mayuri; Kamiki, Teruo; Takemoto, Tsunematsu; Nomoto, Kyosuke. Studies on metabolites produced by Aspergillus terreus var. aureus. I. Chemical structures and antimicrobial activities of metabolites isolated from culture broth. Chemical & Pharmaceutical Bulletin (1983), 31(12), 4543-8.
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Nodules and areas of atelectasis are seen at both bases. He later died.
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It is clearly a relatively small cavitary lesion, and the patient was almost asymptomatic. This response was a ‘stable’ response. The patient was included in the report Denning DW, Lee JY, Hostetler JS, Pappas P, Kauffman CA, Dewsnup DH, Galgiani JN, Graybill JR, Sugar AM, Catanzaro A, Gallis H, Perfect JR, Dockery B, Dismukes WE, Stevens DA, NIAID Mycoses Study Group multicenter trial of oral itraconazole therapy of invasive aspergillosis. Am J Med 1994; 97: 135-144.
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Well demarcated pulmonary infarction is well seen in this close-up of the lung at autopsy in a patient with histologically confirmed invasive aspergillosis. Angio invasion is characteristic of invasive aspergillosis, is associated with a worse prognosis, but is not always seen.
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This 83 year old man presented with weight loss to a lung cancer clinic in mid 2003.
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