Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – chloromethyresorcyloylhydroxyanisinate
Copyright: n/a
Notes:
Species: A. aureusSystematic name: Benzoic acid, 5-(acetyloxy)-2-[2,6-bis(acetyloxy)-3,5-dichloro-4-methylbenzoyl]-3-methoxy-, methyl esterMolecular formulae: C23H20Cl2O10Molecular weight: 526Chemical abstracts number: 89367-82-8Selected references: Inamori, Yoshihiko; Kato, Yoshiaki; Kubo, Mayuri; Kamiki, Teruo; Takemoto, Tsunematsu; Nomoto, Kyosuke. Studies on metabolites produced by Aspergillus terreus var. aureus. I. Chemical structures and antimicrobial activities of metabolites isolated from culture broth. Chemical & Pharmaceutical Bulletin (1983), 31(12), 4543-8.
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Mr RM is 80 and an ex-coal miner.He developed pneumoconiosis from exposure to coal dust. He also developed rheumatoid arthritis and the combination of this disease and pneumoconiosis is called Caplan’s syndrome.
His chest Xray in early 2015 shows extensive bilateral pulmonary shadowing with solid looking nodules superimposed on abnormal lung fields, contraction of his left lung with an elevated diaphragm and a large left upper lobe aspergilloma, displaying a classic air crescent. His CT scan from mid 2014 demonstrates a large aspergilloma in a cavity on the left, with marked pleural thickening around it, which is partially ‘calcified’ towards its base. Inferiorly on other images,remarkable pleural thickening and fibrotic irregular and spiculated nodules are seen, most partially calcified.
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