Secondary metabolites, 3D structure: Trivial name – Butyrolactone II

Date: 26 November 2013

Secondary metabolites, 3D structure: Trivial name – Butyrolactone II

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Notes:

Species: A. terreusSystematic name: 2-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-3-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-5-oxo-, methyl ester, (2R)-Molecular formulae: C19H16O7Molecular weight: 356Chemical abstracts number: 87414-44-6Selected references: Metabolic products of Aspergillus terreus. IX. Biosynthesis of butyrolactone derivatives isolated from strains IFO 8835 and 4100. Nitta, Keiichi; Fujita, Noritaka; Yoshimura, Tadashi; Arai, Kunizo; Yamamoto, Yuzuru. Fac. Pharm. Sci., Kanazawa Univ., Kanazawa, Japan. Chemical & Pharmaceutical Bulletin (1983), 31(5), 1528-33.


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  • Culture plates on different media. A Colonies on CZ at 24oC, B on CYA at 20oC C on SAB at 37oC, D on CYA at 24oC

    persiicolonies

  • D Sinusitis radiology with fluid level

  • C Bronchiectasis white cell scan (right) – left shows a normal scan for comparison

  • B Bronchogram showing bronchiectasis

  • A Bronchogram showing saccular bronchiectasis

  • Mucous containing Charcot-Leyden crystals, stained with H & EA 57 year old woman presented with breathlessness. She had a history of mild asthma for which she occasionally took salbutamol inhaler puffs. The patient underwent a pneumonectomy because of the severity of her disease process, and uncertainty about the diagnosis, prior to serology results being obtained.Serology showed an IgE of 2600, with a strongly positive Aspergillus RAST test and weakly positive Aspergillus precipitins. Material re