Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – Butyrolactone II
Copyright: n/a
Notes:
Species: A. terreusSystematic name: 2-Furancarboxylic acid, 2,5-dihydro-4-hydroxy-3-(4-hydroxyphenyl)-2-[(4-hydroxyphenyl)methyl]-5-oxo-, methyl ester, (2R)-Molecular formulae: C19H16O7Molecular weight: 356Chemical abstracts number: 87414-44-6Selected references: Metabolic products of Aspergillus terreus. IX. Biosynthesis of butyrolactone derivatives isolated from strains IFO 8835 and 4100. Nitta, Keiichi; Fujita, Noritaka; Yoshimura, Tadashi; Arai, Kunizo; Yamamoto, Yuzuru. Fac. Pharm. Sci., Kanazawa Univ., Kanazawa, Japan. Chemical & Pharmaceutical Bulletin (1983), 31(5), 1528-33.
Images library
-
Title
Legend
-
Image A
CT Scan 30/3/99
Showing extreme pleural thickening and 2 small cavities at apex of left lung.
-
A 43 year old with smoking related emphysema was admitted to hospital with two separate episodes of haemoptysis. He had been in good health up to 1989, when he was diagnosed as having bilateral pulmonary tuberculosis. At that time a CT scan revealed a cavity in the left upper lobe (20.8cm2) with adjacent confluent infiltrates and pleural thickening. On bronchoscopic examination no abnormalities were noted and endobronchial biopsies did not reveal hyphae.
Over the next 4 years his condition deteriorated and a CT scan showed the left upper lobe cavity had increased to 40cm2. Itraconazole 400mg daily was prescribed. There was some clinical improvement on itraconazole but patient eventually deteriorated with breathlessness and with significant weight loss.
, 
