Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – austin
Copyright: n/a
Notes:
Species: A. calidoustus, A. niger, A. ustusSystematic name: Spiro[1H-6,11b-methano-4H-furo[3,4-e][3]benzoxocin-9(10H),3′(6’H)-[2H]pyran]-1,4,6′-trione, 7-(acetyloxy)-3,3a,6,7,11,11a-hexahydro-3a-hydroxy-2′,2′,3,6,8,11a-hexamethyl-12-methylene-, (3S,3’S,3aS,6R,7R,11aS,11bS)-Molecular formulae: C27H32O9Molecular weight: 500.55Chemical abstracts number: 61103-89-7 Toxicity: Oral LD50 250 to 375 mg/kg body-weight in day-old cockerels.
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Drug rashes: Drug interactions between steroids and anti-fungal drugs – (ecchymosis)
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Reference: Muco-cutaneous retinoid effects and facial erythema related to the novel triazole antifungal agent voriconazole. Denning, DW & Griffiths, CEM. Clin.Exp Dermatol 2001, 26(8), 648-53.
Courtesy of Dr D Denning, Wythenshawe Hospital, Manchester.(© Fungal Research Trust),
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Micrographs of A. niger conidia & conidial heads provided by Amaliya Stepanova, Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. terreus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Micrographs of A. fumigatus conidia & conidial heads provided by Amaliya Stepanova, , Head of Laboratory pathomorphology and cytology at Kashkin Research Institute, Russian Federation.
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Patients has history of ABPA complicating long standing asthma. His total IgE has fluctuated between 2,200 and 4,600 KU/L, his Aspergillus IgE between 36.3 and 65.4 kAU/L and Aspergillus IgG from 87-154 mg/L. He has been taking long term itraconazole.
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