Secondary metabolites, 3D structure: Trivial name – austin

Date: 26 November 2013

Secondary metabolites, 3D structure: Trivial name – austin

Copyright: n/a

Notes:

Species: A. calidoustus, A. niger, A. ustusSystematic name: Spiro[1H-6,11b-methano-4H-furo[3,4-e][3]benzoxocin-9(10H),3′(6’H)-[2H]pyran]-1,4,6′-trione, 7-(acetyloxy)-3,3a,6,7,11,11a-hexahydro-3a-hydroxy-2′,2′,3,6,8,11a-hexamethyl-12-methylene-, (3S,3’S,3aS,6R,7R,11aS,11bS)-Molecular formulae: C27H32O9Molecular weight: 500.55Chemical abstracts number: 61103-89-7 Toxicity: Oral LD50 250 to 375 mg/kg body-weight in day-old cockerels.


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  • Culture plates on different media. A Colonies on CZ at 24oC, B on CYA at 20oC C on SAB at 37oC, D on CYA at 24oC

    persiicolonies

  • D Sinusitis radiology with fluid level

  • C Bronchiectasis white cell scan (right) – left shows a normal scan for comparison

  • B Bronchogram showing bronchiectasis

  • A Bronchogram showing saccular bronchiectasis

  • Mucous containing Charcot-Leyden crystals, stained with H & EA 57 year old woman presented with breathlessness. She had a history of mild asthma for which she occasionally took salbutamol inhaler puffs. The patient underwent a pneumonectomy because of the severity of her disease process, and uncertainty about the diagnosis, prior to serology results being obtained.Serology showed an IgE of 2600, with a strongly positive Aspergillus RAST test and weakly positive Aspergillus precipitins. Material re