Secondary metabolites, 3D structure: Trivial name – austin

Date: 26 November 2013

Secondary metabolites, 3D structure: Trivial name – austin

Copyright: n/a

Notes:

Species: A. calidoustus, A. niger, A. ustusSystematic name: Spiro[1H-6,11b-methano-4H-furo[3,4-e][3]benzoxocin-9(10H),3′(6’H)-[2H]pyran]-1,4,6′-trione, 7-(acetyloxy)-3,3a,6,7,11,11a-hexahydro-3a-hydroxy-2′,2′,3,6,8,11a-hexamethyl-12-methylene-, (3S,3’S,3aS,6R,7R,11aS,11bS)-Molecular formulae: C27H32O9Molecular weight: 500.55Chemical abstracts number: 61103-89-7 Toxicity: Oral LD50 250 to 375 mg/kg body-weight in day-old cockerels.

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Immune reconstitution syndrome (mucous impaction or obstructing bronchial aspergillosis) complicating pulmonary aspergillosis in AIDS.

Chest X ray (+64 days)
Immune reconstitution syndrome (mucous impaction or obstructing bronchial aspergillosis) complicating pulmonary aspergillosis in AIDS.

Chest X ray (+day 42)
Immune reconstitution syndrome (mucous impaction or obstructing bronchial aspergillosis) complicating pulmonary aspergillosis in AIDS

Chest X ray (+day 14)
Orbital aspergillosis with late fungemia
Chronic fibrosing pulmonary aspergillosis

Chronic fibrosing pulmonary aspergillosis pt RS.
Pleural thickening followed by CNPA

Image G. 14/5/99
Showing progression of the cavity with some debris inside
Pleural thickening followed by CNPA

Image F. 14/5/99
Compare with B, showing progressive enlargement of cavity and formation of fungal ball.
Pleural thickening followed by CNPA

Image E 14/5/99
Showing enlargement of cavity at left apex and formation of a new cavity there.
Pleural thickening followed by CNPA

Image D 30/3/99
One medium sized irregular cavity at left apex
Pleural thickening followed by CNPA

Image C. 30/3/99
Parenchymal or pleural disease adjacent to the mediasternum on the left with diffuse parenchymal disease. Also pleural based nodules bilaterally.