Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – Asterriquinone A3
Copyright: n/a
Notes:
Species: A. terreusSystematic name: 2,5-Cyclohexadiene-1,4-dione, 2-[1-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]-5-[2-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dimethoxy-Molecular formulae: C34H34N2O4Molecular weight: 534Chemical abstracts number: 78723-15-6Selected references: Arai, Kunizo; Masuda, Kikuo; Kiriyama, Noriki; Nitta, Keiichi; Yamamoto, Yuzuru; Shimizu, Sakae (Fac. Pharm. Sci., Kanazawa Univ., Kanazawa 920, Japan). Chem. Pharm. Bull., 29(4), 961-9 (English) 1981.
Images library
-
Title
Legend
-
High resolution CT scan images with reconstruction of 1mm thick slices at approximately 10mm increments. The scan shows moderately severe multi-lobar cylindrical and varicose bronchiectasis predominantly centrally and in the upper lungs. There is no mucus plugging seen.
The features are in keeping with allergic bronchopulmonary aspergillosis
,
,
-
pt.SB – 6/10/98 – bronchocentric granulomatosis. CT scan showing multiple small nodules of variable size in both lung fields, apparently close to the vascular bundles.
-
Bronchial oedema.Remarkably oedematous bronchial mucosa, as seen in ABPA.
-
An example of longstanding allergic bronchopulmonary aspergillosis in a patient who has been steroid dependent for over 15 years showing remarkable kyphoscoliosis and honey combing and fibrosis of both lungs.
-
Recurrent pulmonary shadows 1. 6 Jan 1988 – chest radiograph showing right hilar enlargement, consistent with ABPA.
Recurrent pulmonary shadows 1. 3 Feb 1989 – chest radiograph showing right upper-lobe consolidation and contraction consistent with obstruction of RUL bronchus, in ABPA.
Clearing of pulmonary shadows 3, pt BJ. 5 April 1989 – resolution of shadows seen in February, with a course of corticosteroids.
Recurrence of pulmonary shadows 4, pt BJ. 2 September 1989 – recurrence of pulmonary shadows with an exacerbation of ABPA.
Central bronchiectasis, pt BJ. CT scan of thorax October 1989 showing central bronchiectasis, characteristic of ABPA (and cystic fibrosis).
,
,
,
,
-
A typical example of a wet mount of a sputum sample from a patient with allergic bronchopulmonary aspergillosis.