Secondary metabolites, 3D structure: Trivial name – Asterriquinone A1

Date: 26 November 2013

Secondary metabolites, 3D structure: Trivial name – Asterriquinone A1

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Notes:

Species: A. terreusSystematic name: 2,5-Cyclohexadiene-1,4-dione, 2,5-bis[1-(1,1-dimethyl-2-propenyl)-1H-indol-3-yl]-3,6-dimethoxy-Molecular formulae: C34H34N2O4Molecular weight: 534Chemical abstracts number: 60924-75-6Selected references: Arai, Kunizo; Masuda, Kikuo; Kiriyama, Noriki; Nitta, Keiichi; Yamamoto, Yuzuru; Shimizu, Sakae (Fac. Pharm. Sci., Kanazawa Univ., Kanazawa 920, Japan). Chem. Pharm. Bull., 29(4), 961-9 (English) 1981.


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  • Culture plates on different media. A Colonies on CZ at 24oC, B on CYA at 20oC C on SAB at 37oC, D on CYA at 24oC

    persiicolonies

  • D Sinusitis radiology with fluid level

  • C Bronchiectasis white cell scan (right) – left shows a normal scan for comparison

  • B Bronchogram showing bronchiectasis

  • A Bronchogram showing saccular bronchiectasis

  • Mucous containing Charcot-Leyden crystals, stained with H & EA 57 year old woman presented with breathlessness. She had a history of mild asthma for which she occasionally took salbutamol inhaler puffs. The patient underwent a pneumonectomy because of the severity of her disease process, and uncertainty about the diagnosis, prior to serology results being obtained.Serology showed an IgE of 2600, with a strongly positive Aspergillus RAST test and weakly positive Aspergillus precipitins. Material re