Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – Andibenin B (2)
Copyright: n/a
Notes:
Species: A. stellatusSystematic name: Spiro[5,11a-methano-1H,11aH-fluoreno[4,4a-c]furan-9(3H),3′(6’H)-[2H]pyran]-3,6,6′(5H)-trione, 6a,7,7a,8,10,11-hexahydro-8-hydroxy-2′,2′,5,6a,8-pentamethyl-, (3’S,5S,6aR,7aR,8R,11aS,11bR)-Molecular formulae: C25H30O6Molecular weight: 426Chemical abstracts number: 60451-42-5Selected references: Dunn, Andrew W.; Johnstone, Robert A. W.; King, Trevor J.; Lessinger, Leslie; Sklarz, Benjamin (Robert Robinson Lab., Univ. Liverpool, Liverpool L69 3BX, Engl.). J. Chem. Soc., Perkin Trans. 1, (9), 2113-17 (English) 1979.
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The chest x-ray shows a patient who had a left lung transplanted in May 2003 for cryptogenic fibrosing alveolitis, which was diagnosed post-transplant as sarcoidosis.
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Gross pathology demonstrating the great pleural thickness and two cavities (upper lobe and superior segment of lower lobe) with fragments of fungal mass.
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Histopathological appearance of a fungus ball. Note a conidial head resulting from fungal exposure to the air.
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Histopathological appearance of a fungus ball caused by Scedosporium apiospermum. The presence of anneloconidia differentiates it from Aspergillus.
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Chronic necrotising aspergillosis. Hyaline hyphal and calcium oxalate crystals obtained by needle aspirate biopsy from a diabetic patient with chronic necrotizing aspergillosis caused by Aspergillus niger (Papanicolaou, x 100).
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Aspergillus niger fungus ball and acute oxalosis. Higher magnification of adjacent replicate section.
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Oxalate crystals within renal tubuli (H&E, phase contrast, x 100). This patient developed acute oxalosis.
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Lung surface. Fungus ball, severe parenchymal fibrosis and pleural thickening.
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