Date: 26 November 2013
Secondary metabolites, 3D structure: Trivial name – 3-hydroxyterphenyllin
Copyright: n/a
Notes:
Species: A. candidusSystematic name: [1,1′:4′,1”-Terphenyl]-2′,3,4,4”-tetrol, 3′,6′-dimethoxy-Molecular formulae: C20H18O6Molecular weight: 354Chemical abstracts number: 66163-76-6PubChem URL: Go to PubChem linkSelected references: Kurobane, Itsuo; Vining, Leo C.; McInnes, A. Gavin; Smith, Donald G. (Dep. Biol., Dalhousie Univ., Halifax, NS B3H 4J1, Can.). J. Antibiot., 32(6), 559-64 (English) 1979.
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The chest x-ray shows a patient who had a left lung transplanted in May 2003 for cryptogenic fibrosing alveolitis, which was diagnosed post-transplant as sarcoidosis.
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Gross pathology demonstrating the great pleural thickness and two cavities (upper lobe and superior segment of lower lobe) with fragments of fungal mass.
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Histopathological appearance of a fungus ball. Note a conidial head resulting from fungal exposure to the air.
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Histopathological appearance of a fungus ball caused by Scedosporium apiospermum. The presence of anneloconidia differentiates it from Aspergillus.
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Chronic necrotising aspergillosis. Hyaline hyphal and calcium oxalate crystals obtained by needle aspirate biopsy from a diabetic patient with chronic necrotizing aspergillosis caused by Aspergillus niger (Papanicolaou, x 100).
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Aspergillus niger fungus ball and acute oxalosis. Higher magnification of adjacent replicate section.
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Oxalate crystals within renal tubuli (H&E, phase contrast, x 100). This patient developed acute oxalosis.
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Lung surface. Fungus ball, severe parenchymal fibrosis and pleural thickening.
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