Date: 7 February 2014
After 3 weeks of posaconazole given for chronic pulmonary aspergillosis, patient NC had a remarkable exacerbation of psoriasis. He had had psoriasis for years, with little trouble and almost no treatment. After taking posaconazole 400mg twice daily, he developed psoriatic plaques on his hands for the first time ever. The plaques on his lower legs became confluent. This occurred in association with worsening chest symptoms, notably increased coughing, more breathlessness and increasing oxygen requirement.
Posaconazole was stopped after 3 weeks, and 2 weeks later he was still very symptomatic with his chest. This responded to a 2 week course of corticosteroids, and his psoriasis also improved.
Copyright:
Fungal Research Trust
Notes: n/a
Images library
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Aspergillosis in the coral sea fan Gorgonia ventalina. Sea fan coral Gorgonia ventalina, Florida Keys, USA. Depth ~5 metres, showing a lesion surrounded by a band of purple tissue. Central areas of the lesion are devoid of coral tissue revealing the underlying axial skeleton. The purple areas are devoid of coral polyps and result from the increased production of purple sclerites (small, non-fused, carbonate skeletal elements). The purpled area also indicates the location of high fungal hyphal density and el
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Aspergillosis in the coral sea fan Gorgonia ventalina. In the Caribbean ond offshore USA the sea fan coral species Gorgonia ventalina is undergoing an epizootic due to Aspergillus sydowii infection. This species of Aspergillus is also known to be associated with food contamination and for opportunistic infection in humans.Taken in San Salvador, Bahamas. Bar represents 5cm. This sea fan was heavily colonized by algae.A -tumours and galls B -lesion C -purplingGalls are composed of axial skeleton and scl
