Date: 26 November 2013
These pictures show remarkable curvature of the spine as a result of collapse of the vertebral bodies of the thoracic vertebrae. This is a gross example of steroid-induced osteoporosis. The dose was not large in the last 10 years, typically 5-10mg daily, but multiple high dose courses and slow tapering lead to this outcome.
Her corticosteroid warning card is also demonstrated, as additional steroids are required for any significant illness or surgery, as her adrenal glands had completely atrophied.
Kindly supplied by Prof David Denning, South Manchester University Hospitals NHS Trust, Manchester UK
(© Fungal Research Trust)
Copyright:
Kindly supplied by Prof David Denning, South Manchester University Hospitals NHS Trust, Manchester UK
Notes:
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Test for aflatoxin B1. Standard curve wells in triplicate – columns 9, 10 & 11 – laid out horizontally. Triplicates of 14 samples laid out vertically in rows 2 to 8
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Light microscopical appearance of hepatic tissue in outbreak of aflatoxicosis showing centrilobular degeneration of hepatocytes with vacuolated cytoplasm and apoptoses (top right abnormal)(Haematoxylin and eosin).
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Aspergillus terreus Thom. A Colonies on MEA after one week; B detail of colony showing columnar conidial heads x 44 ; C conidial heads and tip x 920; D conidia x2330
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Aspergillus terreus Thom. Conidial head of Aspergillus terreus. Conidial heads are compact, columnar and biseriate. Conidiophores are hyaline to slightly yellow and smooth walled.
 due to long term steroid use){kind=link}