Date: 1 December 2013
This patient is a 70 yr old, obese diabetic with aortic stenosis and COPD. He was admitted in early March 09, with collapse and loss of conciousness. His lungs appeared normal at this time – CT and X-ray 1. 10 days later he was admitted with increasing shortness of breath and chest X ray (F) showing widespread patchy consolidation. CT scan (B) showed bronchial dilatation, mucus plugging, nodular and bibasal consolidation. Multiple sputum samples grew Aspergillus fumigatus. The patient required intubation and remained in ITU for 160 days.
Bronchoscopy showed plaques in the major airways with more distal airways plugged with secretions resembling “cottage cheese”.There was severe contact bleeding and oedematous mucosa (I & J). Biopsy of the plaques showed fungal hyphae with a branching pattern consistent with aspergillus infection (G & H).
The patient was initially given IV and nebulised amphotericin B whilst on doses of hydrocortisone from 100-400 mg/day. Voriconazole was added with dose optimisation, and amphotericin discontinued. The patient improved gradually with voriconazole treatment over several months and for the latter month, gamma interferon was added into his regime which further improved his CT scan although some shadowing and bronchial wall thickening was still seen (D).
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Images library
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Colony morphology of A.nidulans SRF200 after two days at 37°C
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Aspergillus nidulans. Cell nuclei-Ds red. DsRed fluorescence micrographs showing nuclear distribution in an A.nidulans germling with dsRed stained nuclei
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Cell Biology – Aspergillus nidulans. Cell nuclei-GFP. Nuclear distribution: GFP fluorescence mirographs showing fungal cell morphology and nuclear distribution in A.nidulans. GFP stained nuclei,grown at 25°C in minimal media O/N
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High resolution CT scan of chest.CT scan demonstrating remarkable bronchial wall thickening of the right main bronchus and main branches, in context of longstanding ABPA
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