Initially it was incorrectly diagnosed as a bronchial carcinoma. The material was allergic mucin with mucus and cellular debris arranged in a layered pattern. Cellular debris was almost entirely eosinophils with scattered Charcot-Leyden crystals. A Grocott stain showed multiple branching fungal hyphae, consistent with Aspergillus spp. Subsequently her total IgE rose to 750 KIU/L and Aspergillus specific RAST to 14.9 KUa/L.
PAS stain. An example of Aspergillus fumigatus.
(PAS-stained) in a patient with chronic granulomatous disease showing a 45 degree branching hypha within a giant cell. Rather bulbous hyphal ends are also seem, which is sometimes found inAspergillus spp. infections, histologically. (x800)
