IPA in late stage AIDS - Aspergillus and Aspergillosis

Date: 26 November 2013

IPA in late stage AIDS, pt TB

Notes:

Close up of cavity of left upper-lobe, proven to be invasive pulmonary aspergillosis at autopsy.

Pulmonary aspergillosis in a patient who had AIDS for 3 years (CD4 count. <10/mm³). Right middle-lobe consolidation and a left upper-lobe cavity as seen in a previously normal lung; the diagnosis was made by culture of a bronchoalveolar lavage specimen and was confirmed at autopsy. (This was published in (Khoo S, Denning DW. Aspergillus infection in the acquired immune deficiency syndrome. Clin Infect Dis 1994; 19 (suppl 1): S41-48.)

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Showing 10 posts of 2574 posts found.

Aspergillus fumigatus

Necrotic lung tissue in culture
Af=Colony of Aspergillus fumigatus
B=bacterial colonies
L=lung tissue
A. fumigatus

A photograph of part of the upper lung lobe of an immunosuppressed patient. The lung tissue shows extenive areas of necrosis due to invasive colonisation.
Aspergillus fumigatus

An aspergilloma removed from the lung cavity
A photograph of a cavity in the upper lobe of the lung of a patient with ankylosing spondylitis. Such cavitation,which may be confused with prior tuberculosis, can follow fibrosis.

A photograph of a cavity in the upper lobe of the lung of a patient with ankylosing spondylitis. Such cavitation,which may be confused with prior tuberculosis, can follow fibrosis.
Aspergillus fumigatus

Plugs stained with Methenamine/silverActively growing mycelia of the fungus are a deep brown/black. Counterstaining shows the dense mucus of the plugs as predominantly orange.
Aspergillus fumigatus

Sputum from an asthmatic patient showing plugs(casts). The development of plugs coincided with an increased prevalence and severity of episodes of asthma
Aspergillus clavatus

microscopic characters Conidiophore stipes(C)1300-2800um long:Vesicles(V)40-70um wide,clavate:Phialides(Ph) uniseriate:Conidia(Con)3.5-4.0um long,smooth walled.
Aspergillus fumigatus

microscopic characters Conidiophore stipes(C)225-350um arising from hyphae(Hy):Vesicles(Ves)15-25um wide:Phialides(Ph)uniseriate:Conidia(Con)2.4-3.0um spherical to ovoid,roughened.